Safety First—RVD’s CBD Drug Interaction Checker


CBD is being used to treat many symptoms, has shown potential to help with many diseases, and helps your body improve overall health and wellness. In fact, scientists have proven inflammation to be the number one cause of disease and pain.1 The National Library of Medicine (NIH) has also educated the world on CBD’s inflammatory properties.2 CBD, aka cannabidiol, has been called a “wonder drug,” without irony. If you haven’t tried it and suffer from chronic pain, get some easy-to-take ZERO THC CBD today. It has essentially very few downsides, and it is readily available. However, if you take prescription meds, it’s important to be aware CBD can interact with medications. At RVDCBD safety with our products is a priority. That’s why we’ve created a CBD drug interaction checker for you.

Having Awareness Is Safety—Know CBD’s Side Effects

Generally, CBD is considered safe. However, cannabidiol, like any over-the-counter medication, should be taken with care and purpose. Recent government clinical trials have shown evidence that THC and CBD may slow down or prevent other prescription drugs from breaking down in the body—specifically, medications that use the cytochrome P450 (CYP) enzymes to metabolize into the bloodstream.3 This means the compounds found in THC and or CBD may keep you from getting the benefits you need from medications that interact with cytochrome P450 (CYP) enzymes4. But what are cytochrome P450 (CYP) enzymes? These are a specific group of naturally produced proteins that kick-start the process of breaking drugs down, so your body can use them for their intended purpose. Other than the interference, CBD’s side effects are very mild. But being aware is important.

CBD Side Effects Include5

  • Lightheadedness
  • Dry mouth
  • Drowsiness
  • Nausea
  • Diarrhea

However, CBD—like acetaminophen (aka Tylenol)—in rare cases can cause liver damage. How do you avoid this? Follow dosing instructions. CBD—when taken properly—generally has no severe risks. Like any medication, you should never take more than is recommended. You should never mix CBD with other substances that have the same effect like alcohol is a depressant. If you’re not sure what that dose ought to be, click here.

Taking CBD with other drugs (prescription or over-the-counter) with similar side effects may also amplify the effects and increase your risk for toxicity. In other words, taking CBD with a medication that can cause drowsiness, such as antidepressants, antihistamines, or alcohol may increase your sleepiness and fatigue like when you’re drunk. When drunk, there are other risks like falling, impaired vision, judgment, etc. So, it’s important to read labels and not double up on drugs that react in the same way.


Drug Interaction Checker

Here are the most common drugs or medications that may interact with cannabidiol. They include many painkillers, anti-inflammatories, antipsychotics, antidepressants, anticonvulsants, statins, opioids, and other groups. Does this extensive list mean CBD is not an option? Of course not. All medications have the potential to interact with others. That’s why pharmacists speak to you before you get a new prescription. This list is simply a starting point to discuss with your healthcare provider. RVDCBD cares about you and your safety.

AlcoholChlorzoxazone (Lorzone)Dexamethasone (Decadron)
Alprazolam (Xanax)Clarithromycin (Biaxin)Diazepam (Diastat, Valium)
Amitriptyline (Elavil)Clobazam (Onfi)Diclofenac (Cataflam, Voltaren)
Amlodipine (Norvasc)Clorazepate (Tranxene-SD)Disulfiram (Antabuse)
Carbamacepin (Tegretol, Equetro)Clozapine (Clozaril, FazaClo)Erythromycin
Carisoprodol (Soma)Codeine (Tylenol)Erlotinib (Tarceva)
Chlordiazepoxide (Librium)Cyclosporine (Sandimmune)Eslicarbazepine acetate (Eslicarbazepine)
Chlormethiazole (Heminevrin)Desipramine (Norpramin)Estazolam (ProSom)
Fentanyl (Duragesic, Sublimaze)
Fexofenadine (Allegra)
Flecainide (Tambocor)
Flurazepam (Dalmane)
Flutamide (Eulexin)
Glipizide (Glucotrol)
Halazepam (Pazipam)Klonipin (Clonazepam)Metoprolol (Lopressor, Toprol XL)
Haloperidol (Haldol)Lansoprazole (Prevacid)Morphine
Halothane (Fluothane)Lorazepam (Ativan)Nelfinavir (Viracept)
Ibuprofen (Motrin)Losartan (Cozaar)Nifedipine (Adalat CC, Procardia XL)
Itraconazole (Sporanox, Onmel)Lovastatin (Mevacor)Omeprazole (Prilosec, Omesec)
Ketamine (Ketalar)Meloxicam (Mobic)Ondansetron (Zofran)
Ketoconazole (Nizoral, Extina)Methoxyflurane (Penthrox)Orphenadrine (Norflex)
Oxaliplatin (Eloxatin)
Oxezepam (Serax)
Pantoprazole (Protonix)
Paroxetine (Paxil)
Pentobarbital (Nembutal)
Phenobarbital (Luminal, Solfoton)
Phenytoin (Dilantin)Rifampicin (Rifadin)Testosterone
Piroxicam (Feldene)Risperidone (Risperdal)Theophylline (Theo-Dur, Theo-24, Theocron, Elixophylline)
Progesterone (Endometrin, Prometrium)Ritonavir (Norvir)Thiopental (Pentothal)
Propofol (Diprivan)Rufinamide (Banzel)Topiramate (Topamax)
Propranolol (Inderal)Secobarbital (Seconal)Tramadol (Ultram)
Quazepam (Doral)Temazepam (Restoril)Triazolam (Halcion)
Valproic acid (Depacon)
Venlafaxine (Effexor)
Verapamil (Calan, Isoptin, others)
Warfarin (Coumadin)
Zonisamide (Zonegran)

Summary For RVDCBD’s Drug Interaction Checker

CBD is a natural substance and has many benefits. Like other over-the-counter supplements and medications, you still must proceed with caution. Remember, if you plan on taking CBD, be safe. Keep three simple rules in mind:

  1. Don’t overdose
  2. Don’t mix substances
  3. Check with your healthcare provider 1st, if you take prescriptions

Take this list with you and ask your doctor if any of your medications are processed by CYP450 enzymes. You’ve had RVD’s back, and RVDCBD has yours. Thank you for your continued support and remember, RVDCBD aims for the best not better health, and less pain and inflammation for all. Keep calm and CBD on!




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